PEER-REVIEWED REFEREED ARTICLES
1. Liu HX, Brumovsky P, Schmidt R, Brown W, Payza K, Hodzik L, Pou C, Godbout C, Hökfelt T. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective action via GalR1 and GalR2 receptors. Proceedings of the National Academy of Sciences USA 98(17): 9960-9964 (2001).
2. Brumovsky PR, Shi T-J, Matsuda H., Kopp J, Villar MJ, Hökfelt T.NPY Y1 receptors are present in axonal processes of DRG neurons. Experimental Neurology 174: 1-10 (2002).
3. Matsuda H, Brumovsky PR, Kopp J, Pedrazzini T, Hökfelt T. Distribution of Neuropeptide Y Receptors in Rodent Peripheral Tissues. Journal of Comparative Neurology 449: 390-404 (2002).
4. Fetissov SO, Jacoby AS, Brumovsky PR, Shine J, Iismaa TP, Hökfelt T. Altered hippocampal expression of neuropeptides in seizure-prone GALR1 knockout mice. Epilepsia 44:1022-33 (2003).
5. Brumovsky PR, Bergman E, Liu HX, Hökfelt T, Villar MJ. Effect of a graded single constriction of the rat sciatic nerve on pain behavior and expression of immunoreactive NPY and NPY Y1 receptor in DRG neurons and spinal cord. Brain Research 1006(1): 87-99 (2004).
6. Hygge-Blakeman K, Brumovsky P, Hao J-X, Xu X-J, Hökfelt T, Crawley JN, Wiesenfeld-Hallin, Z. Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury. Brain Research 1025(1-2):152-8 (2004).
7. Holmberg C, Kuteeva E, Brumovsky P, Kahl U, Karlstom H, Lucas GA, Rodriguez J, Westerblad H, Hilke S, Theodorsson E, Berge OG, Lendahl U, Bartfai T, Hökfelt T. Generation and phenotypic characterization of a galanin overexpressing mouse. Neuroscience 133(1):59-77 (2005).
8. Brumovsky P, Stanic D, Shuster S, Herzog H, Villar M, Hökfelt T. The neuropeptide Y2 receptor is present in peptidergic and non-peptidergic sensory neurons. Journal of Comparative Neurology, 489(3):328-48 (2005).
9. Brumovsky P, Hofstetter C, Olson L, Villar MJ, Hökfelt T. The NPY Y1R is expressed in interneurons and projection neurons in the dorsal horn an area X of the rat spinal cord. Neuroscience, 138(4):1361-1376 (2006).
10. Brumovsky P, Villar MJ, Hökfelt T. Tyrosine hydroxylase is expressed in a subpopulation of small dorsal root ganglion neurons in the adult mouse. Experimental Neurology; 200:153-165 (2006).
11. Brumovsky P, Hygge-Blakeman K, Villar MJ, Watanabe M, Wiesenfeld-Hallin Z, Hökfelt T. Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse – possible implications for pain processing. Journal of Chemical Neuroanatomy, 31:204-262 (2006).
12. Brumovsky P, Mennicken F, O’Donnell D, Hökfelt T. Differential distribution and regulation of galanin receptors- 1 and -2 in the rat lumbar spinal cord. Brain Research, 1085:111-120 (2006).
13. Stanić D, Brumovsky P, Fetissov S, Shuster S, Herzog Hand Hökfelt T. Characterization of Neuropeptide Y2 Receptor Protein Expression in the Mouse Brain. I. Distribution in cell bodies and nerve terminals. Journal of Comparative Neurology, 499:357-390 (2006).
14. Brumovsky P, Watanabe M, Hökfelt T. Expression of the vesicular glutamate transporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury. Neuroscience, 147:469-490 (2007).
15. Coronel MF, Brumovsky PR, Hökfelt T, Villar MJ. Differential galanin upregulation in dorsal root ganglia and spinal cord after graded single ligature nerve constriction of the rat sciatic nerve. Journal of Chemical Neuroanatomy, 35:94-100 (2008).
16. McCarthy CJ, Zabbarova IV, Brumovsky PR, Roppolo JR, Gebhart GF, Kanai AJ. Spontaneous Contractions Evoke Afferent Nerve Firing in Mouse Bladders With Detrusor Overactivity. Journal of Urology. 181(3): 1459-1466 (2009).
17. Coronel MF, Musolino PL, Brumovsky PR, Hökfelt T, Villar MJ. Bone marrow stromal cells attenuate injury-induced changes in galanin, NPY and NPY Y(1)-receptor expression after a sciatic nerve constriction. Neuropeptides 43(2): 125-132 (2009).
18. Brumovsky PR, Feng B, Xu L, McCarthy CJ and Gebhart GJ. Cystitis increases colorectal afferent sensitivity in the mouse. Gastroenterology. American Journal of Physiology – Gastrointestinal and Liver Physiology. 297(6):G1250-G1258 (2009).
19. Feng B, Brumovsky PR, Gebhart GF. Differential roles of stretch-sensitive pelvic nerve afferents innervating mouse distal colon and rectum. American Journal of Physiology – Gastrointestinal and Liver Physiology, 298 (3):G402-409 (2010).
20. Brumovsky PR, Seroogy KB, Lundgren KH, Watanabe M, Hökfelt T, Gebhart GF. Some lumbar sympathetic neurons develop a glutamatergic phenotype after peripheral axotomy with a note on VGLUT(2)-positive perineuronal baskets. Experimental Neurology, 230 (2):258-272 (2011).
21. Brumovsky PR, Robinson DR, La JH, Seroogy KB, Lundgren KH, Albers KM, Kiyatkin ME, Seal RP, Edwards RH, Watanabe M, Hökfelt T, Gebhart GF. Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum. Journal of Comparative Neurology, 519(16):3346-66 (2011).
22. La JH, Feng B, Schwartz ES, Brumovsky PR, Gebhart GF. Luminal hypertonicity and acidity modulate colorectal afferents and induce persistent visceral hypersensitivity. American Journal of Physiology – Gastrointestinal and Liver Physiology, 303:G802-809 (2012).
23. Brumovsky PR, La JH, McCarthy CJ, Hökfelt T, Gebhart GF. Dorsal root ganglion neurons innervating pelvic organs in the mouse express tyrosine hydroxylase. Neuroscience, 223:77-91 (2012).
24. Brumovsky PR, Seal RP, Lundgren KH, Seroogy KB, Watanabe M, Gebhart GF. Expression of vesicular glutamate transporters in sensory and autonomic neurons innervating the mouse urinary bladder. Journal of Urology, 189:2342-2349 (2012).
25. Malet M, Vieytes CA, Lundgren KH, Seal RP, Tomasella E, Seroogy KB, Hökfelt T, Gebhart GF, Brumovsky PR. Transcript expression of vesicular glutamate transporters in lumbar dorsal root ganglia and the spinal cord of mice – Effects of peripheral axotomy or hindpaw inflammation. Neuroscience, 248:95-111 (2013).
26. Brumovsky PR, La JH, Feng B, Gebhart GF. Distribution across tissue layers of extrinsic nerves innervating the mouse colorectum – An in vitro anterograde tracing study. Neurogastroenterology and Motility. 26(10):1494-1507 (2014).
27. McCarthy CJ, Tomasella E, Malet M, Seroogy KB, Hökfelt T, Villar MJ, Gebhart GF, Brumovsky PR. Axotomy of tributaries of the pelvic and pudendal nerves induces changes in the neurochemistry of mouse dorsal root ganglion neurons and the spinal cord. Brain Structure and Function 22:1985-2004 (2016).
28. Usach V, Malet M, López M, Lavalle Lucía, Piñero G, Saccoliti M, Cueto A, Brumovsky P, Brusco A and Setton-Avruj P.Systemic transplantation of bone marrow mononuclear cells promotes axonal regeneration and analgesia in a model of Wallerian degeneration. Transplantation, 101:1573-1586 (2017).
29. Coronel MF, Villar MJ, Brumovsky PR, Gonzalez SL. Spinal neuropeptide expression and neuropathic behaviour in the acute and chronic phases after spinal cord injury: Effects of progesterone administration. Peptides, 88: 189-195 (2017).
30. Malet M, Leiguarda C, Gastón G, McCarthy C, Brumovsky P. Spinal activation of the NPY Y1 receptor induces mechanical and cold allodyinia in rats with chronic constriction injury. Peptides, 92:38-45 (2017).
31. Leiguarda C, Coronel MF, Montaner AD, Villar MJ, Brumovsky PR. Long-lasting ameliorating effects of the oligodeoxynucleotide IMT504 on mechanical allodynia and hindpaw edema in rats with chronic hindpaw inflammation. Neuroscience Letters, 666:17-23 (2018).
32. Leiguarda C, McCarthy CJ, Casadei M, Lundgren KH, Coronel MF, Trigosso-Venario H, Seal RP, Seroogy KB, Brumovsky PR . Transcript expression of vesicular glutamate transporters in rat dorsal root ganglion and spinal cord neurons: Impact of spinal blockade during hindpaw inflammation. ACS Chemical Neuroscience 11(17):2602-2614 (2020).
33. Leiguarda C, Potilinski C, Rubione J, Tate P, Villar MJ, Montaner A, Bisagno V, Constandil L, Brumovsky PR. IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model. Journal of Neuroimmune Pharmacology 16(3): 651-666 (2020)
34. Leiguarda C, Villarreal A, Potilinski C, Pelissier T, Coronel MF, Bayo J, Ramos AJ, Montaner A, Villar MJ, Constandil L, Brumovsky PR. Intrathecal Administration of an Anti-nociceptive Non-CpGOligodeoxynucleotide Reduces Glial Activation and Central Sensitization. Journal of Neuroimmune Pharmacology 16(4): 818-834 (2021)
35. IMT504 blocks allodynia in rats with spared nerve injury by promoting the migration of mesenchymal stem cells and by favoring an anti-inflamatory millieu at the injured nerve. Casadei M, Fiore E, Rubione J, Dominguez LM, Coronel MF, Leiguarda C, García M, Mazzolini G, Villar MJ, Montaner A, Constandil L, Romero-Sandoval A, Brumovsky PR. Pain. (2021) doi: 10.1097/j.pain.0000000000002476 Ahead of Print
Review Articles
1. Villar MJ, Cavazzoli C y Brumovsky PR. Capacidad adaptativa del sistema nervioso: Mecanismos de plasticidad neural. Acta Psiquiátrica y Psicológica de América Latina, 44(1): 11-27 (1998).
2. Landry M, Liu HX, Shi TJ, Brumovsky P, Nagy F, Hökfelt T. Galaninergic mechanisms at the spinal level: Focus on histochemical phenotyping”. Neuropeptides 39(3):223-31 (2005).
3. Hökfelt T, Brumovsky P, Shi TJ, Pedrazzini T, Villar M. NPY and pain as seen from the histochemical side. Peptides, 28(2):365-72 (2007).
4. Brumovsky P, Shi, T-J S, Villar MJ, Hökfelt T. 2007. Neuropeptide tyrosine (NPY) and pain. Trends in Pharmacological Sciences, 28(2):93-102 (2007).
5. Brumovsky PR, Gebhart GF. Visceral organ cross-sensitization – an integrated perspective. Autonomic Neuroscience: Basic and Clinical. Review, 153(1-2):106-115 (2010).
6. Brumovsky PR, Gonzalez S, Vivé J, Marchevsky E. Dolor Neuropático – Parte I. Actualización de su definición, mecanismos y diagnóstico. Neurotarget. 6(2):21-28 (2011).
7. Brumovsky PR. VGLUTs in peripheral neurons and the spinal cord – Time for a review. ISRN Neurology, Article ID 8259753, 28 pages (2013).
8. Brumovsky PR. Dorsal root ganglion neurons and tyrosine hydroxylase –An intriguing association with implication for sensation and pain. PAIN®, 157:314-320 (2016)
9. Malet M., Brumovsky PR. VGLUTs and glutamate synthesis – Focus on DRG neurons and pain. Biomolecules, 5:3416-3437 (2016).
10. Usach V, Coronel F, Malet M, Piñero G, Leiguarda C, Casadei M, Villar M, Setton-Avruj P, Brumovsky PR. Bone Marrow-Derived Cells and Peripheral Nerve Injury: Translational Implications for Pain and Regeneration Treatments. Clinical Pharmacology and Translational Medicine, 2:112-124 (2018).
