Marcelo Javier Perone He is a biochemist, graduated from the Faculty of Exact Sciences, and holds a PhD in Biochemical Sciences from the National University of La Plata.

He is a member of the CONICET Scientific and Technological Researcher Career Track as an Independent Researcher, and a Foreign Adjunct Professor at the Laboratory for Immuno-endocrinology, Department of Biomedical Sciences, University of Copenhagen, Denmark. He also completed postdoctoral studies at the University of Manchester (UK), Cedars-Sinai Medical Center (UCLA, USA), and the University of Pittsburgh (USA).

He is a founding member and president of the Marjorie Foundation for Diabetes Research (FuMDiab)

The Laboratory of Immuno-Endocrinology, Diabetes and Metabolism part of the Diabetes Research Institute (DRI)-Federation, a global collaborative initiative between different research centers that focuses on curing diabetes through the induction of immune tolerance, transplantation of islets and other insulin-producing cells, stem cell therapy and regenerative medicine strategies.

The laboratory studies the Diabetes Mellitus with an emphasis on elucidating and understanding the mechanisms responsible for triggering the onset of this disease and sustaining its chronic development. A thorough understanding of these processes provides the necessary foundation for developing more effective therapeutic strategies to prevent, mitigate, and/or cure this disease.

Some of the projects currently under development are:

• Endoplasmic reticulum stress in beta cells.
• Beta-cell hormetic response.
• Study of biological agents and small molecules with the potential to control inflammation in type 2 diabetes and/or induce immune tolerance in type 1 diabetes.
• Strategies aimed at reducing beta-cell senescence as a potential therapy for diabetes.

LAST 5 YEARS

• Orellano MS, Scelza-Figueredo A, Lameroli Mauriz L*, Sétula C*, Argañarás M, Atorrasagasti C, Perone MJ, Andreone L. (2025) A plant-derived dissociated glucocorticoid receptor modulator mitigates glucolipotoxicity in the endocrine pancreas and peripheral tissues: Preclinical data from a mouse model of diet-induced metabolic syndrome. Life Sciences 362:123363. DOI: 10.1016/j.lfs.2024.123363. * third author
• Andreone, Luz. (2024) Neuroimmune axis: linking environmental factors to pancreatic β-cell dysfunction in Diabetes. In Special Issue: Emerging PNI research: future leaders in focus - second edition - Brain, Behavior, & Immunity – Health 43:100926. DOI: 10.1016/j.bbih.2024.100926
• Carolin Höfner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore Dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzynska, Kristian Klindt, Justyna Klusek, Marcelo J. Perone, Robert Bucki, Per Mårten Hägglund, Pontus Gourdon, Kamil Godfryd, Edyta Urbaniak, Malgorzata Borowiak, Michael Wierer, Patrick Edward MacDonald, Thomas Mandrup-Poulsen, Michal Tomasz Marzec. FK506-binding protein participates in proinsulin folding. Biomolecules 2023,13(1), 152.
• Andreone L, Santos AF, Wailemann RAM, Terra LF, Gomes VM, Macedo da Silva J, Rosa-Fernandes L, Sogayar MC, Palmisano G, Labriola L and Perone MJ. Cotransplantation of marginal mass allogeneic islets with 3D culture-derived adult human skin cells improves glycemia in diabetic mice. Braz. J Med Biol Res 2023;56:e12611.
• Andreone L, Fuertes F, Sétula C, Barcala Tabarrozzi AE, Orellano MS, Dewey RA, Bottino R, De Bosscher K and Perone MJ. Compound A attenuates proinflammatory cytokine-induced endoplasmic reticulum stress in beta cells and displays beneficial therapeutic effects in a mouse model of autoimmune diabetes. Cellular and Molecular Life Sciences (2022); 79:587.
• Valdez SN, Alonso Amorin MA, Alvarez Yuseff MF, Andreone L, Cerrone G, Ledesma IM, Matejic A, Pelayo LN, Perone MJ, Trabucchi A, Frechtel GD. Practical guide for requesting humoral markers of autoimmunity and genetic studies in Diabetes Mellitus. Journal of the Argentine Diabetes Society (2022); 56:15-18.
• Backe M, Jin C, Andreone L, Sankar A, Agger K, Helin K, Madsen AN, Poulsen SS, Bysani M, Karl Bacos, Ling C, Perone MJ, Holst B and Mandrup-Poulsen T. The lysine demethylase KDM5B regulates islet function and glucose homeostasis. Journal of Diabetes Research (2019) vol. 2019, Article ID 5451038, 15 pages.
• Ghiasi SM, Dahlby T, Andersen CH, Haataja L, Petersen S, Omar-Hmeadi M, Yang M, Pihl C, Bresson SE, Khilji MS, Klindt K, Cheta O, Perone MJ, Tyrberg B, Prats C, Barg S, Tengholm A, Arvan P, Mandrup-Poulsen T, Marzec MT. The endoplasmic reticulum chaperone glucose-regulated protein 94 is essential for proinsulin handling. Diabetes (2019) 68(4):747-760.
• Atorrasagasti C, Onorato A, Gimeno ML, Andreone L, Garcia M, Malvicini M, Fiore E, Bayo J, Perone MJ, Mazzolini GD. SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice. Clinical Science (2019) 133(2):351-365.
• Andreone L, Gimeno ML, and Perone MJ. Interactions between the neuroendocrine system and T lymphocytes in diabetes. Front. Endocrinol (Lausanne) 2018 May 17;9:229.

Dr. Marcelo Javier Perone - Associate Professor in charge of Biochemistry I and II, Nutrition program, FCB - Independent Researcher - CONICET -  mperone-conicet@austral.edu.ar

Dr. Luz Andreone - Adjunct Professor of Biochemistry II and in charge of Cell and Molecular Biology, Nutrition program, FCB - Adjunct Researcher - CONICET - landreone-conicet@austral.edu.ar

Lic. Miranda Orellano - Doctoral Fellow - CONICET - Morellano-conicet@austral.edu.ar

Biochemist Carolina Sétula - Teaching Assistant in Biochemistry I and II, Nutrition program - Doctoral Fellow – CONICET -  CSetula@austral.edu.ar

Ms. Andrea Scelza-Figueredo - Teaching Assistant for Biostatistics II, Research Methodology II and General Chemistry, Nutrition program - Doctoral Fellow - ANPCyT - ascelza-iimt@austral.edu.ar

Ingrid Pensado Evans, Esq. - Teaching Assistant in Cell and Molecular Biology and Biochemistry II, Nutrition program - Doctoral Fellow - CONICET - ipensado-iimt@austral.edu.ar

LAST 5 YEARS:

• "Integrated stress response (ISR) in pancreatic beta cells: Identification of specific eIF2α-kinases in response to glycolipotoxicity and/or inflammation" Research Grant - Basic Area. Argentine Diabetes Society (2025). PI: MJ Perone.

• "Modulation of endoplasmic reticulum stress generated by glycolipotoxicity in pancreatic beta cells: a study of the influence of age and sex in a murine model of type 2 diabetes mellitus (T2DM)" Grant for Scientific Research Projects of the Universidad Austral (2025-2027). Principal Investigator: Dr. Luz Andreone.
• "Strategies aimed at reducing beta cell senescence as a potential therapy for type 2 diabetes" National Agency for Scientific and Technological Promotion (PICT-2021-GRF-TII-00241). Period 2023-2027. Principal Investigator: Dr. Luz Andreone.
• "Search for new therapeutic targets through multi-tissue transcriptomic analysis for the comprehensive treatment of common metabolic diseases." Co-Principal Investigator: Dr. Luz Andreone. Grant from the National Agency for Scientific and Technological Promotion (PICT-2021-Applied-II), for the period 2023-2024.
• "Stress adaptation of beta cells and consequences for insulin production." Principal Investigator. Grant from the Universidad AustralPI: MJ Perone
• "Hormetic response of the beta cell." Research Grant - Basic Area. Argentine Diabetes Society. PI: MJ Perone.
• Strategies aimed at reducing beta cell senescence as a therapy for type 2 diabetes. Research Grant - Basic Area. Argentine Diabetes Society. PI: L Andreone.
• "Protective effect of selective glucocorticoid receptor modulators against gluco/lipotoxicity-induced stress in beta cells: Therapeutic potential in type 2 diabetes." Florencio Fiorini Grant for Biomedical Research, 2022. Principal Investigator: Dr. Luz Andreone.
• Protective effects of Compound A against beta-cell dysfunction in diabetes. Principal Investigator: Dr. Luz Andreone. National Agency for Scientific and Technological Promotion (PICT-2018-0719). Period 2020-2022.
• Study of the anti-inflammatory activity of interleukin-37 in autoimmune diabetes. Principal Investigator: Dr. Marcelo J. Perone. National Agency for Scientific and Technological Promotion (PICT-2018-01577). Period 2020-2022.
• Grant from the Argentine Diabetes Society. Basic Area. (2019-2020) “Protective effect of a selective glucocorticoid receptor ligand against β-cell dysfunction in type 2 diabetes mellitus”. Period 2019-2020.

• Special Mention for Oral Communication in the Area of ​​Metabolism: Attenuation of glucolipotoxicity on beta cell function and peripheral tissue in a diet-induced obesity model: effect of compound A (CpdA). Orellano MS, Scelza-Figueredo A, Sétula C, Lameroli Mauriz L, Argañaras M, Montechi P, Atorrasagasti C, Perone MJ, Andreone L69th Annual Meeting of the SAIC, CABA, November 19-22 2024.
• Second Prize Gador Foundation: Hormesis mediated by IL-1β protects pancreatic -cells from dysfunction and death. Sétula C, Orellano MS, Argañarás M, Andreone LPerone MJ. LXVIII Annual Meeting of the Argentine Society for Clinical Research. Mar del Plata, November 15-18. 2023.
• The Sugar Science & DKNET D-Challenge, 2nd Cash Award 2022. "Unraveling the role of a metabolic sensor protein family in beta-cells under type 1 diabetes pathology." Authors: Miranda Orellano, Carolina Setula, Luz Andreone and Marcelo J. Perone.
• Award for the best work in the area of ​​basic research. Sétula C, Rodriguez-Valero IJ, Orellano MS, Andreone L, Perone MJ. The beta cell adapts to an unfavorable inflammatory environment through hormesis: experimental evidence in vitro. XXIII Argentine Congress of Diabetes, September 28 - October 1, 2022. Rosario, Argentina.
• Mention for the best Poster in the area of ​​Metabolism and Nutrition, awarded by the Argentine Society of Clinical Research. “Activation of NRF2 pathway by compound A protects against oxidative stress and b-cell dysfunction.” Authors: Andreone L, Fuertes F, Ariolfo L, De Bosscher K, Perone MJ. Joint Meeting of SAIC, SAFE, and SAP, November 13-16, 2019, Mar del Plata, Argentina.

• First Prize for Best Poster of the Regenerative Medicine and Cell Therapy Session, awarded by SAIC. “A novel naturally occurring splice variant of the human TGF-β type II receptor (TβRII) encodes a truncated soluble molecule.” Marcela Soledad Bertolio, Tania Melina Rodríguez, Alejandra Carrea, Jorge Velasco Zamora, Marcelo Javier Perone, Ricardo Alfredo Dewey. LXI Annual Meeting of the Argentine Society for Clinical Research (SAIC), November 15-19, 2016, Mar del Plata, Argentina.
• Selected in 2014 by the scientific committee made up of experts appointed by the Ministry of Science, Technology and Productive Innovation, Novo Nordisk Pharma Argentina SA, Argentine Diabetes Society (SAD) and members of the University of Copenhagen to participate in the “Academic, Scientific, Technological and Innovation Program in Diabetes and Biotechnology applied to Health MINCyT-NOVO-NORDISK. Activity: Argentine Scientists.

• Address: Av. Pte. Perón 1500, Derqui, Pilar, Buenos Aires
• E-mail: mperone-conicet@austral.edu.ar; landreone-conicet@austral.edu.ar