Dr. María Florencia Coronel
Dr. Coronel is a Biochemist, graduated from the University of Buenos Aires, and holds a PhD in Biomedical Sciences from the Universidad Austral and Independent Researcher at CONICET.
She is an associate professor, in charge of the subject of Pain Pathophysiology, and academic secretary of the Academic Council of the Doctoral Program in the Faculty of Biomedical Sciences. She is also a member of the Board of Directors of the Institute for Translational Medicine Research.
He is a member of the Pain Research Special Interest Group of the Argentine Association for the Study of Pain, the International Association for the Study of Pain (IASP), and the Peripheral Nerve Society (PNS).
Dr. Coronel completed her doctoral studies at this institution, under the supervision of Dr. Marcelo Villar, and has since dedicated herself to studying the mechanisms involved in the generation and maintenance of persistent pain of various etiologies, primarily associated with injuries to the nervous system. For several years, she has focused her research on the study of pain associated with cancer, particularly neuropathic pain associated with peripheral neuropathy induced by different chemotherapeutic drugs. She currently leads experimental and clinical studies aimed at analyzing the prevalence, clinical characteristics, underlying mechanisms, associated risk factors, and potential preventive and therapeutic strategies for this severe and frequent adverse effect of cancer treatment.
La Dr. Graciela Luján Mazzone She is a member of the CONICET Scientific Researcher Career Track as an independent researcher. Dr. Mazzone earned her undergraduate degree in Biological Sciences from the Faculty of Exact and Natural Sciences at the University of Buenos Aires. She subsequently completed her doctoral studies in Molecular Medicine at the University of Trieste, Italy, with a scholarship from the Italian Ministry of Foreign Affairs and Cooperation. Since her postdoctoral studies in the Department of Neuroscience at the International School for Advanced Studies of Trieste (SISSA), Italy, she has focused on the study of the molecular mechanisms and basis of spinal cord injuries.
Currently, Dr. Mazzone is developing a line of research on spinal pathologies using different experimental approaches and a multifactorial approach in murine models. She is also a lecturer at the Faculty of Biomedical Sciences of the Universidad Austral and member of ICCUAL.
Our group develops an integrated research program that combines preclinical and clinical approaches to study cancer-related pain. We have a multidisciplinary team of biologists, biotechnologists, biochemists, physicians, psychologists, and nurses.
Preclinical studies focus primarily on chemotherapy-induced peripheral neuropathy, a common and severe adverse effect of cancer treatment. We use experimental models, behavioral assessments, and biochemical and molecular assays to:
Clinical trials involve pediatric and adult cancer patients, in collaboration with the Oncology and Comprehensive Care services of the Austral University Hospital. These trials aim to:
Our goal is for these advances to contribute to improving the quality of life of cancer patients, offering new tools to understand, prevent and treat pain in all its dimensions.
This line of research focuses on the study of the mechanisms and molecular bases involved in the development of locomotor disorders and neuropathic pain following spinal injuries, in order to identify therapeutic targets.
Specifically, this work focuses on characterizing a murine model of traumatic and chemical spinal cord injury. The goal is to identify the molecular and cellular mechanisms that can promote spinal regeneration through combined neuroprotective strategies based on the application of novel drugs and/or regenerative therapies. Based on the results obtained, it is hoped that new targets can be identified for designing translational therapeutic strategies that will limit, or at least reduce, the consequences of acute spinal cord injury in its earliest possible phase, thereby mitigating the loss of locomotor function and the development of neuropathic pain.
“Multitargeting neuroimmune pathways: novel candidates for pain relief.” MF Coronel, MJ Villar, PR Brumovsky. Trends in Pharmacological Sciences S0165-6147(25)00181-6 (2025), https://doi.org/10.1016/j.tips.2025.08.005
“Early oral administration of THC:CBD formulations prevent pain-related behaviors without exacerbating paclitaxel-induced changes in weight, locomotion, and anxiety in a rat model of chemotherapy-induced neuropathy." D Soriano, PR Brumovsky, MJ Villar, MF Coronel. Psychopharmacology (2025), https://doi.org/10.1007/s00213-025-06778-y
“Prevalence of oxaliplatin-induced neuropathy: sex-related differences”. CA Miguel, L Cavasotto, C Lopez Sartorio, N Marcolini, F Gayet, MF Coronel. Medicina (Buenos Aires) 85(3):501-510 (2025).
“Prevalence, Severity, and Persistence of Chemotherapy-Induced Peripheral Neuropathy in Early-Stage Breast Cancer Patients Treated with Paclitaxel: an Observational Study in a Referral Hospital in Latin America.” D Soriano, M Arana Amantini, G Cordoba, Y Vanni, M Varela, C Paletta, MF Coronel. Journal of Critical Care and Emergency Medicine 3(12):1-6 (2024), https://doi.org/10.47363/JCCEM/2024(3)166
“Excitotoxic spinal damage induced by kainic acid impairs locomotion, alters nociception, and reduces CREB nuclear translocation.” B Zylberberg, AM Suburo, MF Coronel, G Mazzone. Behavioral Brain Research 18:475:115219 (2024), https://doi.org/ 10.1016/j.bbr.2024.115219
“Chemotherapy-induced neuropathy in Argentinean pediatric patients: impact of combination therapy.” D Soriano, G Santos Chocler, MA Varela, MF Coronel. European Journal of Pediatrics (2024), https://doi.org/10.1007/s00431-024-05638-9.
“Resveratrol evoked neuroprotective effects and improved foot posture following kainate-induced excitotoxic damage to the mouse spinal cord.” B Zylberberg, M Poodts, J Roncoroni, MF Coronel, G Mazzone. Neuropharmacology 250 (2024), https://doi.org/10.1016/j.neuropharm.2024.109906
"Changes in the expression of endocannabinoid system components in an experimental model of chemotherapy-induced peripheral neuropathic pain: evaluation of sex-related differences.” MV Noya Riobó, CA Miguel, DB Soriano, PR Brumovsky, MJ Villar, MF Coronel. Experimental Neurology, Special Issue on Cannabinoids 359:114232 (2023), https://doi.org/10.1016/j.expneurol.2022.114232
"An update to pain management after spinal cord injury: from pharmacology to circRNAs". GL Mazzone, MF Coronel, M Mladinic, C Sámano. Reviews in the Neurosciences (2022), https://doi.org/10.1515/revneuro-2022-0089
"Sex-related differences in oxaliplatin-induced changes in the expression of transient receptor potential channels and their contribution to cold hypersensitivity." CA Miguel, MV Noya Riobó, PR Brumovsky, MJ Villar, MF Coronel. Neuroscience Letters 788:136863 (2022), https://doi.org/10.1016/j.neulet.2022.136863
"Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved.” CA Miguel, MV Noya Riobó, GL Mazzone, MJ Villar, MF Coronel. Neurochemistry International 150: 105188 (2021). Special Issue "Oxidative Stress in Chronic and Acute CNS Insults. https://doi.org/10.1016/j.neuint.2021.105188
"Circular RNAs: the novel actors in pathophysiology of spinal cord injury.” Sámano C, Mladinic M, Mazzone GL. Frontiers in Integrative Neuroscience 15:758340 (2021), https://doi.org/10.3389/fnint.2021.758340
"Nicotine Neurotoxicity Involves Low Wnt1 Signaling in Spinal Locomotor Networks of the Postnatal Rodent Spinal Cord.” Kaur J, Mazzone GL, Aquino JB and Andrea Nistri A. International Journal of Molecular Sciences 22(17) 9572 (2021) https://doi.org/10.3390/ijms22179572
"Case report of neuron-binding IgGs in ALS patient serum in Argentina.” Di Mauro GC, De Ambrosi B, Uchitel OD, Mazzone GL. Journal of Neurocritical Care 4(2):1-5 (2021) https://doi.org/10.31038/JNNC.2021423
"GABAergic Mechanisms Can Redress the Tilted Balance between Excitation and Inhibition in Damaged Spinal Networks. Mazzone GL, Mohammadshirazi A, Aquino JB, Nistri A, Taccola G. Molecular Neurobiology 58(8):3769–3786 (2021), https://doi.org/10.1007/s12035-021-02370-5
"Resveratrol prevents oxaliplatin-induced neuronal damage and allodynia through anti-oxidant and anti-inflammatory mechanisms.” MD Recalde, CA Miguel, MV Noya Riobó, SL Gonzalez, MJ Villar, MF Coronel. Brain Research 1748:147079 (2020) https://doi.org/10.1016/j.brainres.2020.147079
"Anti-allodynic and anti-inflammatory effects of 17a-hydroxyprogesterone caproate in oxaliplatin-induced peripheral neuropathy.” CA Miguel, MC Raggio, MJ Villar, SL González, MF Coronel. Journal of the Peripheral Nervous System 24(1):100-110 (2019), https://doi.org/10.1111/jns.12307
