Welcome to the Research Group in Microbiota y microbiome applied to the clinic, which we carry out mainly from our laboratory called Biolab.
La mission Our research team's objective is to study and analyze the human microbiota and microbiome, focusing on potential clinical applications, working with cutting-edge techniques and methodologies worldwide in collaboration with top-level institutions, such as NIST (National Institute for Standards and Technology) in the United States and companies such as Illumina, Inc. and Zymo Research.
We are strongly interested in characterizing and achieving a deep understanding of the relationship between microbiota, microbiome, and different conditions in health and disease processes.
We conduct comprehensive analyses of the human microbiota and microbiome within an interrelated context of clinical, metabolic, anthropometric, and dietary interventions to study the relationships among these key characteristics and thus bridge the gap between science and potential approaches to disease diagnosis and treatment.
Specifically, from the perspective of the microbiome, we begin by characterizing its composition to further identify and study potential active metabolites and metabolic pathways related to direct actions on our metabolism.
From a methodological and scientific perspective, we focus on studying all the steps and processes involved in our objective: from sample extraction to the interpretation of the results, following each and every step in accordance with international standards.
We are a research, teaching and technology transfer laboratory framed within a scientific and business ecosystem located on the Campus of the Universidad AustralIn Pilar, Argentina, the Austral University Hospital, Sirius Software, the Faculty of Biomedical Sciences, the Institute for Translational Medicine Research (IIMT), the Faculty of Engineering, and the Austral Business Park are key components of an ecosystem that enriches and empowers us.
rtaussig@austral.edu.ar
This study focuses on identifying the strengths and limitations of bioinformatics tools that process raw genomic data, providing information on alpha and beta diversity, differential analysis, and correlations. To this end, we are working with public datasets from published articles, simulating datasets, and processing data from our own research projects.
Based on previously published work in this area worldwide, we are building a database and related analyses that describe relationships between, primarily, microorganisms present in the microbiota and active metabolic pathways in both the microorganisms themselves and the host organism. As time progresses, the detailed impact of microbial metabolites on host signaling pathways becomes more evident.
In collaboration with the Gastroenterology Laboratory of the Institute of Immunology, Genetics, and Metabolism (INIGEM) at Hospital de Clínicas, we seek to improve the quality of life of people with obesity, obesity and prediabetes, and obesity and type 2 diabetes through a two-year follow-up with a plant-based lifestyle medicine intervention and diet. We also seek to study the potential stage transition of people with obesity/prediabetes/type 2 diabetes who regress toward control or who evolve toward profiles similar to type 2 diabetes based on clinical parameters and microbiota and microbiome profiles. We have registered this clinical trial with ClinicalTrials.gov under code NCT05372445.
Preprints
2023
Ignacio Cassol, Mauro Ibañez, Juan Pablo Bustamante
https://www.researchsquare.com/article/rs-2595260/v1
2023
Samuel P. Forry, Stephanie L. Servetas, Jason G. Kralj, Keng Soh, Michalis Hadjithomas, Martha Carlin, Maria G de Amorim, Benjamin Auch, Matthew G Bakker, Thais F Bartelli, Juan P. Bustamante, Ignacio Cassol, Mauricio Chalita, Emmanuel Dias-Neto, Daryl M. Gohl, Jekaterina Kazantseva, Muyideen T. Haruna, Peter Menzel, Bruno S Moda, Lorieza Neuberger-Castillo, Diana N Nunes, Isha R. Patel, Rodrigo D. Peralta, Adrien Saliou, Rolf Schwarzer, Samantha Sevilla, Isabella KTM Takenaka, Jeremy R. Wang, Rob Knight, Dirk Gevers, Scott A. Jackson
https://www.biorxiv.org/content/10.1101/2023.04.28.538741v2
Cassol, RD Peralta, R. Taussig, JP Bustamante
https://semipyp.es/pdf/anales/vol2_num1.pdf
icassol@austral.edu.ar Mariano Acosta 1611
